Research in the Aiello lab uses genetic and molecular approaches to investigate fundamental processes in cellular physiology, in particular, carbohydrate metabolism and intracellular calcium homeostasis. Our work has shown that these two distinct, and essential, processes are linked at the cellular level. Specifically, there is considerable evidence to suggest that intracellular calcium homeostasis is influenced by intermediates in carbohydrate metabolism, and that these molecules may play important regulatory functions. Altering their cellular levels results in changes to cellular calcium homeostasis, which in turn results in defects in protein folding in the endoplasmic reticulum, and altered stress responses to a variety of extracellular stressors. This work has broader implications beyond the research lab as recent evidence suggests that some of the underlying pathologies of Alzheimer’s disease may be due to a fundamental dysregulation of cellular calcium homeostasis. Experimental approaches in the lab are a combination of classical yeast genetics and modern techniques in molecular biology, including RNA-seq and whole genome sequence analysis.