Cell and Cancer Biology
My research focuses on how the activity and specificity of an enzyme called the proteasome affects the biology of a cell. The activities of proteasomes are essential for almost every process in the eukaryotic cell. My lab uses a variety of genetic, biochemical, and molecular biology approaches to specifically study a proteasome activator called PA28gamma, which is a prominent marker of several cancers and the autoimmune disease, systemic lupus erythematosus. In my lab, we currently pursue questions examining the role that PA28/proteasomes play in regulating cell division as well as apoptosis. Through understanding the regulation of proteasome activity, we hope to understand the biological processes that lead to cancerous transformations and aberrant cellular function. Students will learn tissue culture techniques as well as animal husbandry. Please see me directly for further information about opportunities in my lab.